Gliclazide Properties Category  Pharmaceutical Raw Materials, Fine Chemicals, Bulk drug Standard Medical standard Shelf life 2 years  Storage  should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. Test Item Standard: USP Identification IR spectrum similar to that of RS HPLC retention time similar to that of RS Related substance Total impurities: NMT0.3% Single impurity: NMT0.1% Heavy metals NMT 10ppm Loss on drying NMT0.5% Residue on ignition NMT0.1% Assay 98.5%-101.0% Gliclazide Application liclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insulin secretagogues, which stimulates β cells of the pancreas to release insulin. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insulin containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxide. Gliclazide Packaging and Shipping Packaging:Packing: Net each in 25kg or 1000kg plastic woven bag, lined with PE bag. Shipping:It can be according to the customer’s request Gliclazide Storage Room temperature