Adefovir Typical Properties
Item
Specifications
Appearance
White or slight White powder
Identification
Maximum absorption at 261 nm
Loss on drying
≤1.0%
Related substance
Any other impurity ≤0.5%
Total impurity ≤1.0%
Assay
≥98.0%
Brand name
Fousi chemical
Adefovir Usage
Adefovir is an acyclic nucleoside analogue of adenosine monophosphate, which is phosphorylated into an active metabolite, adefovir diphosphate, under the action of cellular kinases.
Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) in the following two ways: one is to compete with the natural substrate deoxyadenosine triphosphate, and the other is to cause the extension of the DNA chain after integration into viral DNA.
The inhibitory constant (Ki) of adefovir diphosphate on HBV DNA polymerase is 0.1 μM, but the inhibitory effect on human DNA polymerase α and γ is weak, with Ki values of 1.18 μM and 0.97 μM, respectively.
Adefovir Packaging and Shipping
Packing: 25kg/cardboard drum
Delivery: by ocean
Adefovir Storage
Store in a cool, ventilated warehouse, the storage temperature should not exceed 37℃ It should be stored separately from oxidants and food chemicals, and should not be mixed.
