Pro-xylane CAS#439685-79-7

Bose has a wide range of biological activities. It can promote the secretion of glycosaminoglycan (GAG) , induce the biosynthesis of GAG and proteoglycan (PG) in the superficial cortex, and promote the synthesis of collagen, effectively promote the epidermis-dermis close connection, make the skin stronger and more flexible. And PX non-toxic, easy to biodegrade, will not accumulate in the biological body, often used in cosmetics.

Promote GAG synthesis

PX, which consists of xylose linked to glycoside ligands, provides a binding site for soluble GAG and can initiate GAG generation and assembly independent of endogenous core proteins [11] , the level of free GAG was greatly increased. Pineau et al found that PX could increase the expression of HA receptor CD44 in the corticosteroid induced skin atrophy model in vitro. PX can also act on Keratinocyte, enhance its GAG synthesis, promote Fibroblast growth factor 10(FGF-10)-dependent cell proliferation and migration, and have a positive role in epithelial repair [12] .

Promote collagen regeneration

PX can play a role in Dej, induce the protein deposition of basement membrane zone (BMZ) and the expression of Dej structural and functional proteins, and increase the expression of collagen type IV and VII, gag is added to the network of type IV collagen to improve age-related skin laxity and thus reduce wrinkles

The application of PX in cosmetics

PX has anti-aging, moisturizing and healing effects when applied to skin. The biological phenomenon of skin aging can be divided into two categories: endogenous aging and exogenous aging [16] . Internal aging is caused by internal physiological factors, the performance of aging caused by fine lines, thin epidermis, dermis atrophy. External aging is the effect of all external factors on the skin, such as UV radiation, pollution and cigarette smoke exposure leading to deep wrinkles, sagging skin, and Telangiectasia [17-18] . Over the past 20 years, cosmetic medicine has made significant progress in combating age-related skin ageing, with effective treatments currently including BOTOX injections, skin laser therapy and topical skin care. The latter focuses on small molecules or natural extracts such as retinol, estrogens, growth factors and antioxidants, etc. . As a cosmetic material, PX is widely used in many kinds of skin care products, including common creams and special nano-preparations, and its effect has been confirmed by many studies.

Applications in other areas

The safety, effectiveness and Biocompatibility of PX need to be further and more comprehensively studied. Combined with modern molecular biotechnology, immune technology and other disciplines, the study of PX's performance will be more perfect, its application prospect is also more broad