Guanidine hydrochloride CAS#50-01-1

1.1 NameGuanidine hydrochloride1.2 Synonyms

1-methylguanidine hydrochlorideAmino(imino)methanaminium chlorideAMINOFORMAMIDINE HCLAminoformamidine hydrochlorideAminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chlorideAminoformamidine hydrochloride,Guanidinium chloride,Guanidium chlorideAminomethanamidine hydrochloridCough.

EINECS 200-002-3GdmClGuanidine (hydrochloride)guanidine chlorhydrateGuanidine chlorideGuanidine HClGuanidine HydrochlorGuanidine hydrochloride (1:1)Guanidine monohydrochlorideGuanidine, hydrochloride (1:1)Guanidine, monohydrochlorideGuanidinehydrochlorideGuanidinhydrochloridguanidinium chlorideguanidinium hydrochlorideGUANIDIUM CHLORIDEGUHYhydrochloric acid guanidineMFCD00013026Redness.

Redness.

Pain.usafek-749ZYZUM &&HCl

2.1 Density

1.18 g/mL at 25 °C(lit.)

2.1 Melting point

180-185 °C(lit.)

2.1 Boiling point

132.9 °C at 760 mmHg

2.1 Refractive index

n20/D 1.465

2.1 Flash Point

34.2 °C

2.1 Precise Quality

95.02500

2.1 PSA

75.89000

2.1 logP

1.14090

2.1 Solubility

H2O: 6?M, clear, colorless

2.2 Appearance

DryPowder; DryPowder, Liquid

2.3 Storage

Store at RT.

2.4 Chemical Properties

White cryst. powder

2.5 Color/Form

White to slightly yellow

2.6 Odor

Odorless

2.7 PH

4.5-5.5 (100g/l, H2O, 20℃)

2.8 Water Solubility

H2O: 2280 g/L (20 oC)

2.9 Stability

Stable. Hygroscopic. Incompatible with strong oxidizing agents.

2.10 StorageTemp

Store at RT.

3.1 Definition

ChEBI: An aminocarboxamidine, the parent compound of the guanidines.

3.2 Purification Methods

Crystallise the hydrochloride from hot methanol by chilling to about -10o, with vigorous stirring. The fine crystals are filtered through fritted glass, washed with cold (-10o) methanol, dried at 50o under vacuum for 5hours. (The product is purer than that obtained by crystallisation at room temperature from methanol by adding large amounts of diethyl ether.) [Kolthoff et al. J Am Chem Soc 79 5102 1957, Beilstein 3 H 86, 3 II 71, 3 III 160, 3 IV 150.] Guanidine hydrochloride Preparation Products And Raw materials Preparation Products

3.3 Usage

Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase. Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

4.1 Symbol

GHS07;

4.1 Hazard Codes

Xi,Xn

4.1 Signal Word

Warning

4.1 Risk Statements

22-36/38

4.1 Safety Statements

26-36-22

4.1 Exposure Standards and Regulations

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies currently marketed prescription drug products, incl guanidine hydrochloride, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Guanidine Hydrochloride/

4.2 Octanol/Water Partition Coefficient

log Kow = -1.63 (est)

4.3 Hazard Declaration

H302 + H332; H315; H319

4.3 DisposalMethods

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

4.4 RIDADR

NONH for all modes of transport

4.4 Caution Statement

P261; P280; P301 + P312 + P330; P304 + P340 + P312; P305 + P351 + P338; P337 + P313

4.4 Formulations/Preparations

Oral: Tablets 125 mg guanidine hydrochloride (Schering Canada for Key Pharm) /Guanidine hydrochloride/

4.5 WGK Germany

1

4.5 RTECS

MF4300000

4.5 Safety

Safety Information of Guanidine hydrochloride (50-01-1):
Hazard Codes: Xn,Xi
Risk Statements: 22-36/38?
22:? Harmful if swallowed
36:? Irritating to the eyes???
38:? Irritating to the skin?
Safety Statements: 26-36-22
22:? Do not breathe dust
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:? Wear suitable protective clothing

4.6 Sensitive

Hygroscopic

4.7 Specification

White cryst. powder
Safety Statements:26-36-22
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
22:Do not breathe dust

4.8 Toxicity

LD50 orally in Rabbit: 655.3 – 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg

• COA (Certificate Of Analysis)