Climbazole Typical Properties
Item
Standard
Test Results
Identification
A.H-NMR:Comply with the structure
Complies
B.LC-MS:Comply with the structure
Complies
C.The IR spectrum of sample should be identical with that of reference standard;
Complies
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the
Standard preparation, as obtained in the Assay.
Complies
Crystallinity
meets the requirements.
Complies
Loss on drying
≤2.0%
0.19%
Heavy metals
≤10 ppm
<10ppm
Water
≤1.0%
0.1%
Sulphated ash
≤0.5%, determined on 1.0 g.
0.009%
Related substances
Unspecified impurities: for each impurity
≤0.10%
<0.10%
Total Impurity
≤0.5%
0.18%
Purity
≥99.0%
99.7%
Assay
99.0%~101.0% (anhydrous substance).
99.8%
Microbiological Analysis
Total plate count
≤1000cfu/g
Complies
Yeast and Moulds
≤100cfu/g
Complies
E. Coli.
Absent
Negative
Salmonella
Absent
Negative
S.aureus
Absent
Negative
Storage
Preserve in well-closed, light-resistant and airtight containers.
Complies
Climbazole Application
Climbazole,Broad-spectrum bactericidal performance, mainly used for relieving itching recuperated anti-dandruff shampoo, hair shampoo, can also be used for antibacterial soap, shower gel, liquid drug toothpaste, mouthwash, etc
Climbazole Uses
Ganbaosu is a racemate composed of equimolar amounts of (R)- and (S)-ganbaosu. The IUPAC name is (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl- 3,3-Dimethylbutan-2-one is a topical antifungal agent used to treat human fungal skin infections. It can be included in over-the-counter anti-dandruff shampoo formulations and skin treatment compositions to treat dandruff and eczema where the cause is fungal infection. Ganbaosu mainly non-competitively blocks the synthesis of lanosterol 14α-demethylase (also known as fungal CYP51) in the P450 enzyme, thereby inhibiting the biosynthesis of ergosterol, an important component of plasma fungal cell membranes, and making fungal cells death.
It has broad-spectrum bactericidal properties. It is mainly used for anti-itching and anti-dandruff conditioning shampoos and hair care shampoos. It can also be used for antibacterial soap, shower gel, medicated toothpaste, mouthwash, etc.
Shampoo, shower gel, soap
Climbazole Packaging and Shipping
Packaging:25g/drum
