Tubastatin A hydrochloride CAS#1310693-92-5

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Chemical Name: Tubastatin A hydrochloride
CAS No.: 1310693-92-5
Molecular Formula: C20H21N3O2.HCl
Molecular weight: 371.86058
Sample: Available

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Products Description of Tubastatin A hydrochloride CAS#1310693-92-5

Tubastatin a hydrochloride is a chemical

Product Application of Tubastatin A hydrochloride CAS#1310693-92-5

Basic Info

Numbering system

Properties

Basic Info

Chemical Name	N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide hydrochloride (1:1)
Synonyms	Tubastatin A (Hydrochloride);Tubastatin A HCl;
CAS No.	1310693-92-5
Molecular Formula	C20H22ClN3O2
Molecular Weight	371.86100
PSA	57.50000
LogP	3.92730

Numbering system

Properties

Product Application of Tubastatin A hydrochloride CAS#1310693-92-5

An efficient and selective HDAC6 inhibitor, IC50:15 NM. TubastatinAdemonstrates1093-foldselectivityoverHDAC1(IC50VALUESOF15NM FOR HDAC6VS16.4? ΜM FOR HDAC1) . Tubastatin a is more electivethan the known hdac6 inhibitor tubacinatallisozymes except thdac8. The TUBASTA PATENTHDAC6 inhibitor with an IC 50 value of 15 nm. , it demonstrates over 1, Chemical Book 000-fold selection against ALLOTHERHDAC ISOFORMS (IC 50 & GT; 16 μm) , excluding DAC8(IC 50 = 0.9 μm) . Tubatinatin a NDUCES Α-tubulin hyperacetylationat 2.5 μm in primary corticalneuron cultures. INAMODELO foxidativestressinducedbyglutathione depletion, tubastatinadisplaysdose-dependentneuronalprotectionofprimary corticalneuronculturesat5-10 ΜM.

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