Guanidine Hydrochloride
CAS# 50-01-1

Part 2: In-depth

It is unstable and can be hydrolyzed in an aqueous solution to produce ammonia and urea, so it is as toxic as urea, and guanidine and its derivatives are generally more toxic than urea.

1. Used as intermediate in medicine, pesticide, dyestuff, and another organic synthesis. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methyl pyrimidine, 2-amino-4,6-dimethylpyrimidine, and is an intermediate in the manufacture of sulfadiazine, sulfa-dimethyl pyrimidine, sulfa-dimethyl pyrimidine, and other sulfonamide drugs.
2. guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate and cyclizes to 2,4-diamino-6-hydroxypyrimidine, which is used in the synthesis of the anti-anemic drug folic acid. It is also used as an antistatic agent for synthetic fibers.
3. Also used as a protein denaturant.
4. Used as a strong denaturant in experiments to extract total cellular RNA. The guanidine hydrochloride solution dissolves proteins, leading to disruption of the cell structure, destruction of the nucleoprotein secondary structure, and dissociation from the nucleic acid, in addition, RNA enzymes can be inactivated by reducing agents such as guanidine hydrochloride.

Part III: Summary

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