Ethyl chloroacetate CAS# 105-39-5

Used as a solvent, also used as raw material for organic synthesis use as a pharmaceutical, spice, also used as solvent use ethyl chloroacetate can be used as raw material for the preparation of insecticide azoxystrobin and herbicide ethyl chlorothalonil, also used in the synthesis of antitumor drug 5-fluorouracil and spices, etc. Used as a solvent and raw material for organic synthesis. Used to make the antitumor drug 5-fluorouracil, spices, and toxic gas. Used as a solvent for organic synthesis, used as a solvent and raw material for organic synthesis. Used to make anti-tumor drug 5-fluorouracil, fragrance, and military gas. Produced by esterification of chloroacetic acid with ethanol. Direct esterification of chloroacetic acid and ethanol with sulfuric acid as catalyst. The crude ester is neutralized by alkali washing, water washing, and distillation to obtain the finished product. Chloroacetic acid B Chemicalbook ester is obtained by esterification of chloroacetic acid and ethanol catalyzed by sulfuric acid. The reaction equation is as follows: ClCH2COOH+C2H5OH[H2SO4]→ClCH2COOC2H5+H2O Add chloroacetic acid, ethanol, and benzene to the esterification pot, turn on the stirrer, slowly add sulfuric acid, heat to reflux, continuously evaporate benzene-water azeotropes, by condensing, separator stratification to the water generated by esterification, and reflux benzene to the esterification pot, when there is no longer water evaporation Cooling, discharge, crude ester washed with saturated sodium bicarbonate solution and water to neutral, dried by anhydrous calcium chloride and then distilled, collected 144-146 ℃ fraction is ethyl chloroacetate finished product, content ≥ 99.0%, yield 85%.