3-Hydroxy-1-AdaMantane Carboxylic Acid CAS# 42711-75-1

Used in the synthesis of adamantane derivatives and adalbene. 1-Adamantaneacetic acid can be obtained by reaction with vinylidene chloride. 1-Adamantaneacetic acid is then brominated and hydrolyzed to 3-hydroxy-1-adamantane acetic acid, and 1,3-adamantane acetic acid can be obtained by reaction with vinylidene chloride.

1-Adamantanol and acetanilide undergo Fucetylation reaction at room temperature in 98% sulfuric acid medium, which can directly synthesize 1,3-bis(4-acetaminophen)adamantane, and synthesize 1,3-bis(4-anilino)adamantane from its alkali hydrolysis. This synthetic route has the advantages of higher reaction yield and easy purification, which largely facilitates the synthesis of 1,3-adamantane diaryl derivatives.

1-Adamantanol, 4-bromophenol was used as the raw material to make adapalene, and the 2-1-Adamantane-4-bromophenol product was catalyzed by concentrated sulfuric acid; then methylated with dimethyl sulfate to obtain 2-1-Adamantane-4-bromophenyl ether, and the Grignardized product of this bromophenyl ether was then reacted with methyl 6-Bromo-2-naphthoic acid to produce 6-3-1-Adamantane-4-methoxyphenyl-2-naphthoic acid methyl naphthalene-2-carboxylate. The product was saponified in the presence of sodium hydroxide to hydrolyze the adapalene.